河北工业大学化工学院

胡秀丽

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研究员，博士生导师

huxiuli@hebut.edu.cn

教育背景：

2004-2009，中国科学院长春化学研究所，博士

2000-2004，吉林大学，高分子科学与工程系，本科

工作履历：

2019-至今，河北工业大学，化工学院，研究员

2015-2016，美国北卡莱罗纳州立大学，访问学者

2012-2019，中国科学院长春化学研究所，副研究员

2009-2012，中国科学院长春化学研究所，助理研究员

研究领域与承担项目：

研究领域：主要围绕生物医用高分子材料的设计、合成及其在药物控释、肿瘤治疗、免疫治疗等领域开展工作。开发了多种基于聚氨基酸、聚碳酸酯方面的功能化聚合物，实现了小分子化疗药物、光敏剂、免疫治疗药物的高效担载和可控释放。构建了肿瘤微环境靶向聚集、响应释放的纳米药物和肿瘤疫苗。

基金和项目：

1. 国家自然科学基金面上项目“IDO小分子抑制剂纳米化及其对肿瘤免疫治疗的影响”2020.01-2023.12，主持；

2. 国家自然科学基金面上项目“肿瘤微环境响应的anti-PD-1/PD-L1抗体囊泡用于癌症化疗/免疫协同治疗”2018.01-2021.12，主持。

3. 中央引导地方科技发展资金项目“硒功能化聚氨基酸的合成及生物应用” 2022.07-2024.12，主持；

4. 河北省自然科学基金面上项目“基于乳酸-乏氧机制纳米药物的构建及肿瘤联合治疗研究，2022.01-2024.12，主持；

奖励与荣誉：

河北省“三三三人才工程”第三层次人才，天津市线上线下一流本科建设课程。

代表性著作：

[1] Pei Qing, Zhou Shiyu, Lu Shaojin, Hao Dengyuan, Xiang Xiujuan, Hu Xiuli,* Jing Xiabin, Xie Zhigang* Ferric Ion-Driven Chlorin E6 Nanoparticles: Simple and Effective Multimodal Theranostics. Adv. Funct. Mater. 2023, 2304205.

[2] Zhang Meng, Geng Shiqun, Yan Gaojie, Dong Jincheng, Ji Haifeng, Feng Yi, Hu Xiuli*, Liu Binyuan*, Zhang Xiaojie*. Nucleophilic ring-opening of thiocyclic carbonates: A scheme to prepare sulfhydryl-rich binders for high-performance lithium-sulfur batteries. Journal of Colloid and Interface Science, 2023, 633, 1–10

[3] Zhang Huijuan, Pan Jiaxin, Wang Tingting, Lai Yi,* Liu Xiaoying, Chen Fangmin, Xu Leiming, Qu Xiongwei,* Xiuli Hu,* and Yu Haijun* Sequentially activatable polypeptide nanoparticles for combinatory photodynamic chemotherapy of breast cancer. ACS Applied Materials & Interfaces, 2022, 14, 35, 39787–39798.

[4] Zhang Jimin, Deng Meigui, Shi Xiaoguang, Zhang Chuangnian, Qu Xiongwei, Hu Xiuli *, Wang Weiwei *, Kong Deling, Huang Pingsheng*. Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy. Bioactive materials 2021, 6, 3300

[5] Hu Xiuli, Zhang Huijuan, Wang Zejun, Chin Ying Angela Shiu, and Gu Zhen* Microneedle array patches integrated with nanoparticles for therapy and diagnosis, Small Struct. 2021, 2, 2000097.

[6] Zhou Shiyu, Hu Xiuli,* Xia Rui, Liu Shi, Pei Qing, Chen Guang,* Xie Zhigang,* Jing Xiabin. A paclitaxel prodrug activatable by irradiation in a hypoxic microenvironment. Angew. Chem. Int. Ed. 2020, 59, 2-10 .

[7] Li Chaonan, Zhang Wei, Liu Shi, Hu Xiuli,* Zhigang Xie* Mitochondria-targeting organic nanoparticles for enhanced photodynamic/photothermal therapy. ACS Applied Materials & Interfaces, 2020, 12, 30077-30084.

[8] Wang jian; Pei Qing; Xia Rui; Liu Shi; Hu Xiuli*; Xie Zhigang*; Jing Xiabin; Comparison of redox responsiveness and antitumor capability of paclitaxel dimeric nanoparticles with different linkers, Chemistry of Materials, 2020, 32(24): 0-10719-10727.

[9] Xia, Rui; Pei, Qing; Wang, Jian; Wang, Zhanfeng; Hu, Xiuli*; Xie, Zhigang; Redox responsive paclitaxel dimer for programmed drug release and selectively killing cancer cells, Journal of Colloid and Interface Science, 2020, 580: 785-793.

[10] Xia Rui, Zheng Xiaohua, Hu Xiuli,* Shi Liu, Zhigang Xie*. Photothermal-controlled generation of alkyl radical from organic nanoparticles for tumor treatment. ACS Appl. Mater. Interfaces 2019, 11, 5782−5790.

[11] Pei Qing, Hu Xiuli*, Zheng Xiaohua, Liu Shi, Li Yang, Jing Xiabin, Xie Zhigang*. Light-activatable red blood cell membrane-camouflaged dimeric prodrug nanoparticles for synergistic photodynamic/chemotherapy. ACS Nano. 2018, 12, 1630-41.

专利申请与授权情况：