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胡秀丽


屏幕截图 2024-02-25 165803.png

研究员,博士生导师

huxiuli@hebut.edu.cn

教育背景:

2004-2009,中国科学院长春化学研究所,博士

2000-2004,吉林大学,高分子科学与工程系,本科

工作履历:

2019-至今,河北工业大学,化工学院,研究员

2015-2016,美国北卡莱罗纳州立大学,访问学者

2012-2019,中国科学院长春化学研究所,副研究员

2009-2012,中国科学院长春化学研究所,助理研究员

研究领域与承担项目:

研究领域:主要围绕生物医用高分子材料的设计、合成及其在药物控释、肿瘤治疗、免疫治疗等领域开展工作。开发了多种基于聚氨基酸、聚碳酸酯方面的功能化聚合物,实现了小分子化疗药物、光敏剂、免疫治疗药物的高效担载和可控释放。构建了肿瘤微环境靶向聚集、响应释放的纳米药物和肿瘤疫苗。

基金和项目:

1.    国家自然科学基金面上项目“IDO小分子抑制剂纳米化及其对肿瘤免疫治疗的影响”2020.01-2023.12,主持;

2.    国家自然科学基金面上项目“肿瘤微环境响应的anti-PD-1/PD-L1抗体囊泡用于癌症化疗/免疫协同治疗”2018.01-2021.12,主持。

3.    中央引导地方科技发展资金项目“硒功能化聚氨基酸的合成及生物应用” 2022.07-2024.12,主持;

4.    河北省自然科学基金面上项目“基于乳酸-乏氧机制纳米药物的构建及肿瘤联合治疗研究,2022.01-2024.12,主持;

奖励与荣誉:

河北省“三三三人才工程”第三层次人才,天津市线上线下一流本科建设课程。

代表性著作:

[1]      Pei Qing, Zhou Shiyu, Lu Shaojin, Hao Dengyuan, Xiang Xiujuan, Hu Xiuli,* Jing Xiabin, Xie Zhigang* Ferric Ion-Driven Chlorin E6 Nanoparticles: Simple and Effective Multimodal Theranostics. Adv. Funct. Mater. 2023, 2304205.

[2]      Zhang Meng, Geng Shiqun, Yan Gaojie, Dong Jincheng, Ji Haifeng, Feng Yi, Hu Xiuli*, Liu Binyuan*, Zhang Xiaojie*. Nucleophilic ring-opening of thiocyclic carbonates: A scheme to prepare sulfhydryl-rich binders for high-performance lithium-sulfur batteries. Journal of Colloid and Interface Science, 2023, 633, 1–10

[3]      Zhang Huijuan, Pan Jiaxin, Wang Tingting, Lai Yi,* Liu Xiaoying, Chen Fangmin, Xu Leiming, Qu Xiongwei,* Xiuli Hu,* and Yu Haijun* Sequentially activatable polypeptide nanoparticles for combinatory photodynamic chemotherapy of breast cancer. ACS Applied Materials & Interfaces, 2022, 14, 35, 39787–39798.

[4]      Zhang Jimin, Deng Meigui, Shi Xiaoguang, Zhang Chuangnian, Qu Xiongwei, Hu Xiuli *, Wang Weiwei *, Kong Deling, Huang Pingsheng*. Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy. Bioactive materials 2021, 6, 3300

[5]      Hu Xiuli, Zhang Huijuan, Wang Zejun, Chin Ying Angela Shiu, and Gu Zhen* Microneedle array patches integrated with nanoparticles for therapy and diagnosis, Small Struct. 2021, 2, 2000097.

[6]      Zhou Shiyu, Hu Xiuli,* Xia Rui, Liu Shi, Pei Qing, Chen Guang,* Xie Zhigang,* Jing Xiabin. A paclitaxel prodrug activatable by irradiation in a hypoxic microenvironment. Angew. Chem. Int. Ed. 2020, 59, 2-10 .

[7]      Li Chaonan, Zhang Wei, Liu Shi, Hu Xiuli,* Zhigang Xie* Mitochondria-targeting organic nanoparticles for enhanced photodynamic/photothermal therapy. ACS Applied Materials & Interfaces, 2020, 12, 30077-30084.

[8]      Wang jian; Pei Qing; Xia Rui; Liu Shi; Hu Xiuli*; Xie Zhigang*; Jing Xiabin; Comparison of redox responsiveness and antitumor capability of paclitaxel dimeric nanoparticles with different linkers, Chemistry of Materials, 2020, 32(24): 0-10719-10727.

[9]      Xia, Rui; Pei, Qing; Wang, Jian; Wang, Zhanfeng; Hu, Xiuli*; Xie, Zhigang; Redox responsive paclitaxel dimer for programmed drug release and selectively killing cancer cells, Journal of Colloid and Interface Science, 2020, 580: 785-793.

[10]   Xia Rui, Zheng Xiaohua, Hu Xiuli,* Shi Liu, Zhigang Xie*. Photothermal-controlled generation of alkyl radical from organic nanoparticles for tumor treatment. ACS Appl. Mater. Interfaces 2019, 11, 5782−5790.

[11]   Pei Qing, Hu Xiuli*, Zheng Xiaohua, Liu Shi, Li Yang, Jing Xiabin, Xie Zhigang*. Light-activatable red blood cell membrane-camouflaged dimeric prodrug nanoparticles for synergistic photodynamic/chemotherapy. ACS Nano. 2018, 12, 1630-41.

专利申请与授权情况:

[1]      紫杉醇类二聚体、制备方法及其制剂, 授权公告号CN 106349193 B

[2]      一种含有苯硼酸的N-羧基环内酸酐单体和聚氨基酸及其制备方法与应用 申请号:202311511421.6


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