张计敏

职称：副教授，博士生导师

电子邮箱：2018124@hebut.edu.cn

教育背景：

2015-2018，南开大学，博士

2009-2012，南开大学，硕士

2005-2009，青岛科技大学，本科

工作履历：

2024-至今，河北工业大学化工学院，副教授、博导

2018-2024，河北工业大学化工学院，讲师、硕导

学术任职：

中国生物材料学会会员

研究领域与承担项目：

研究领域：

1.生物医用高分子材料

2.刺激响应高分子材料

3.智能传感功能材料

基金和项目：

1.国家自然科学基金，青年项目，2024-2026，主持

2.河北省自然科学基金，青年项目，2020-2022，主持

3.河北省高等学校科学技术基金，青年项目，2022-2024，主持

4.南开大学、中国医科院医工所，开放课题，2022-2024，主持

5.国家自然科学基金，联合基金重点项目，2021-2024，参与

6.河北工业大学本科教育教学改革研究项目，2024-2025，主持

奖励与荣誉：

元光学者启航岗B，天津市课程思政教学名师，国家奖学金研究生指导教师，优秀毕设指导教师，本科教学质量优秀教师，化工学院2023年科技工作先进个人.

代表性著作：

[1] Peng Zhao, Yu Zhang, Xiaoai Chen, Chang Xu, Jingzhe Guo, Meigui Deng, Xiongwei Qu, Pingsheng Huang*, Zujian Feng*, Jimin Zhang*. Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin-Resistant Staphylococcus Aureus-Infected Dynamic Wound Healing, Advanced Science, 2023, 2206585. (IF= 17.521) 热点论文，高被引论文

[2] Chang Xu, Jiqing Zhang, Junxian Zhang, Danting Li, Xiaozhe Yan, Yuxuan Gu, Meihui Zhong , Hui Gao, Qiang Zhao, Xiongwei Qu*, Pingsheng Huang*, Jimin Zhang. Near Infrared-Triggered Nitric Oxide-Release Nanovesicles with Mild-Photothermal Antibacterial and Immunomodulation for Healing MRSA-Infected Diabetic Wounds. Advanced Healthcare Materials, 2024, 2402297. (IF= 10)

[3] Xiaoai Chen, Chang Xu, Peng Zhao, Yu Zhang, Jingzhe Guo, Xiuli Hu, Hui Gao, Chuangnian Zhang*, Xiongwei Qu*, Jimin Zhang*. A multichannel Ca²⁺ nanomodulator amplifies exogenous and endogenous calcium overload for efficient antitumor and antimetastasis therapy, Chemical Engineering Journal, 2023, 142478. (IF= 16.744）

[4] Jimin Zhang, Meigui Deng, Xiaoguang Shi, Chuangnian Zhang, Xiongwei Qu, Xiuli Hu*, Weiwei Wang*, Deling Kong, Pingsheng Huang*. Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy[J]. Bioactive Materials, 2021, 6(10): 3300-3313. (IF= 18.9）

[5] Junxian Zhang, Meigui Deng, Chang Xu, Danting Li, Xiaozhe Yan, Yuxuan Gu, Meihui Zhong, Hui Gao, Yingchun Liu, Jiqing Zhang*, Xiongwei Qu*, Jimin Zhang*_。Dual-Prodrug-Based Hyaluronic Acid Nanoplatform Provides Cascade-Boosted Drug Delivery for Oxidative Stress-Enhanced Chemotherapy. ACS Applied Materials & Interfaces, 2024, 16, 50459−50473. (IF= 8.3)

[6] Yu Zhang, Peng Zhao, Xiaoai Chen, Chang Xu, Jingzhe Guo, Xiongwei Qu, Xiuli Hu, Hui Gao, Pingsheng Huang*, Jimin Zhang*. Near Infrared-Activatable Methylene Blue Polypeptide Codelivery of the NO Prodrug via π−π Stacking for Cascade Reactive Oxygen 3 Species Amplification-Mediated Photodynamic Therapy, ACS Applied Materials & Interfaces, 2023, 15: 12750-12765. (IF= 10.383）

[7] Yue Zhang*, Liyuan Tian, Jimin Zhang*, Meihui Zhong. pH-Responsive Hyperbranched Polymer Scaffolds for Polymer and Peptide Conjugation through Molecular Recognition: Synthesis and Self-Assembly. Biomacromolecules, 2025, 26, 5: 2960–2970. (IF= 5.5)

[8] Danting Li, Junxian Zhang, Jialin Zhang, Jiaqi Ding, Haoxuan Sun, Xiongwei Qu*, Jimin Zhang*. Skin-Adaptive Hydrogel Patch with Antitumor Activity for Tumor Elimination. ACS Applied Polymer Materials, 2025, 7, 7, 4414–4426. (IF= 4.4)

[9] Jimin Zhang, Jingzhe Guo, Junxian Zhang, Danting Li, Meihui Zhong, Yuxuan Gu, Xiaozhe Yan, Pingsheng Huang*. Heparin and Gelatin Co-Functionalized Polyurethane Artificial Blood Vessel for Improving Anticoagulation and Biocompatibility. Bioengineering, 2025, 12(3), 304. (IF= 3.8)

[10] Jimin Zhang, Huijuan Song, Shenglu Ji, Xiaomin Wang, Pingsheng Huang, Chuangnian Zhang, Weiwei Wang*, Deling Kong*. NO prodrug-conjugated, self-assembled, pH-responsive and galactose receptor targeted nanoparticles for co-delivery of nitric oxide and doxorubicin. Nanoscale, 2018, 10, 4179-4188. (IF= 8.307）

[11] Jimin Zhang, Jianing Wang, Yongzhen Wei, Cheng Gao, Xuejiao Chen, Wei Kong, Deling Kong*, Qiang Zhao*. ECM-mimetic heparin glycosamioglycan-functionalized surface favors constructing functional vascular smooth muscle tissue in vitro. Colloids and Surfaces B: Biointerfaces, 2016, 146: 280-288. (IF= 6.0）

[12] Chunyong Liang, Jiying Song, Yongguang Zhang, Yaping Guo, Meigui Deng, Wei Gao*, Jimin Zhang*. Facile Approach to Prepare rGO@Fe3O4 Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy. Nanoscale Research Letters, 2020, 15(86): 1-11. (IF= 5.418）

[13] Peiqiong Zhao, Meigui Deng, Yongfang Yang*, Jimin Zhang*, Yue Zhang*. Synthesis and Self-Assembly of Thermoresponsive Biohybrid Graft Copolymers Based on a Combination of Passerini Multicomponent Reaction and Molecular Recognition[J]. Macromolecular Rapid Communications, 2021, 42(21): 2100424. (IF= 5.006）

[14] Yue Zhang*, Rong Zhao, Yan Qin, Jianguo Yi, Jimin Zhang*, Xiaoai Chen. Synthesis and self-assembly of hyperbranched multiarm copolymer peptide conjugates based on light-induced metal-free ATRP[J].Polymer Chemistry, 2023, 14, 2930-2939. (IF= 4.6）

[15] 廖日鑫, 李国华, 张计敏*, 胡秀丽, 瞿雄伟. 聚氨基酸在肿瘤免疫治疗中的应用, 高分子材料科学与工程, 2021, 37(8): 182-190. (EI）

专利申请与授权情况：

1. 张计敏，赵鹏，邓梅桂，陈小爱，张宇，瞿雄伟. 一种多功能抗菌水凝胶敷料的制备方法及应用，ZL 202111312519.X. 授权专利

2. 张计敏，邓梅桂，赵鹏，张宇，陈小爱. 一种用于级联递送药物的透明质酸纳米给药系统的制备方法，ZL202211307057.7. 授权专利

3. 张计敏，陈小爱，张宇，赵鹏，徐畅，郭靖喆，瞿雄伟. 一种多通道促肿瘤钙超载的Ca²⁺纳米调节剂制备方法，ZL2023100 36155. X. 授权专利

4. 张计敏，邓梅桂，赵鹏，张宇，陈小爱，徐畅，郭靖喆，瞿雄伟. 一种光敏剂和一氧化氮前药的给药系统其及制备方法，ZL202310022636.5. 授权专利

5. 张计敏，张宇，赵鹏，陈小爱，徐畅，郭靖喆，瞿雄伟. 一种一氧化氮与顺铂共递送纳米粒子及其制备和应用，CN116492314A. 公开专利

6. 赵强，孔德领，张计敏，王淑芳. 酶催化可控释放一氧化氮的新型生物材料及其制备方法与应用，2015-9-30，中国， ZL201310296773.4. 授权专利.

招生专业：

化学工程与技术（博士），化学（学硕），化学工程（专硕）