韩亚平 现任职称/职务：讲师，硕导 通讯地址：天津市北辰区河北工业大学化工学院B305 邮政编码：300401 电子邮箱：2019070@hebut.edu.cn 联系电话：（13212270268） |
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研究领域 |
1.有机电合成 2.有机合成方法学 3.过渡金属催化 |
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讲授课程 |
《药物合成反应》、《高等有机化学》、《天然药物化学》、《药物分析实验》 |
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学术经历 |
2014-09-2019-06 兰州大学硕博连读 2019-07-至今 河北工业大学任教 |
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学术兼职 |
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学术成就 |
学术成就: 工作集中于有机合成化学中新方法、新策略研究，具体工作涵盖电促金属催化碳氢键官能团化、路易斯酸或布朗斯特酸催化炔丙醇串联反应、钯催化卤代吲哚Heck脱芳构化反应等多个领域，以药物小分子骨架的高效合成为主。迄今为止，申请人在重要学术期刊（Nat. Commun., Chin. J. Catal., Org. Lett.等）发表SCI论文50余篇，以通讯作者或第一作者发表SCI论文28篇，其中SCI二区及以上论文22篇，包括Chin. J. Catal. 1篇，Org. Lett. 2篇，J. Org. Chem. 7篇，Adv. Synth. Catal. 8篇，Chin. J. Chem. 1篇，Org. Chem. Front. 2篇等。近五年论文情况如下： 1. Wang, Yun-Zhao; Sun, Bing; Guo, Jian-Feng; Zhu, Xiao-Yu; Gu, Yu-Cheng; Han, Ya-Ping; Ma, Cong; Mei, Tian-Sheng; Enantioselective reductive cross-couplings to forge C(sp2)-C(sp3) bonds by merging electrochemistry with nickel catalysis, Nat. Commun., 2025, 16, 1108-1108 (SCI 一区). 2. Xi, Yi-Fan; Gao, Rui-Xing; Fang, Ping; Han, Ya-Ping*; Ma, Cong; Mei, Tian-Sheng*; Siteselective benzylic C-H oxidation through mediated electrolysis, Chinese J Catal, 2024, 67, 54-60 (SCI 一区). 3. Zhou Sun, Jia-Xuan Liu, Lin Shi, Ming Yang, Yuan Wang, Ya-Ping Han,* Xiaojun Yao*, and Yong-Min Liang. New Synthetic Approaches for the Construction of Enantioenriched Molecules Bearing Quaternary Stereocenters. Adv. Synth. Catal. 2024, 366, 4294−��������4322 (SCI 二区). 4. Xiang Li, Ning-Yu Guo, Qing-Hui Liu, Ya-Ping Han,* Hong-Yu Zhang,* and Li-Zeng Peng*. Lewis Acid-Catalyzed Tandem Annulation of Propargylic Alcohols with 2-Allylphenols and Their Anti-tumor Activities. Asian J. Org. Chem. 2024, e202400265 (SCI 三区). 5. Jia-Xuan Liu, Sheng-Qi Xu, Ya-Ping Han,* Yong-Min Liang; Recent Advances in Cyclization Reactions of 1,6-Enynes. Adv. Synth. Catal. 2024, 366, 1220−��������1268 (SCI 二区). 6. Qing-Hui Liu, Yue Ma, Hong-Yu Zhang, Yuecheng Zhang, * Jiquan Zhao, Xiaohui Cao,* Ya-Ping Han,* and Yong-Min Liang; Experimental and Computational Studies on the Palladium-catalyzed Intramolecular Dearomatization, Electrophilic Addition, Intermolecular Coupling Sequence. Org. Chem. Front. 2024, 11, 1357-1365 (SCI 一区TOP). 7. Xue-Song Zhang, Ya-Ping Han,* Yong-Min Liang; Recent Advances in the Cascade Cyclization Reactions of 1,7-Enynes. Adv. Synth. Catal. 2024, 366, 324−��������356 (SCI 二区). 8. Xi-Yan Ren, Xiang-Xuan Feng, Hong-Yu Zhang, Yuecheng Zhang,* Jiquan Zhao, Ya-Ping Han,* Yong-Min Liang; Lewis Acid Catalyzed [4 + 2] Annulation of Propargylic Alcohols with 2-Vinylanilines. J. Org. Chem. 2023, 88, 16007−��������16017 (SCI 二区TOP). 9. Yue Ma, Qing-Hui Liu, Ya-Ping Han,* Palladium-Catalyzed Enantioselective Intramolecular Heck Dearomative Annulation of Indoles with N‑��������Tosylhydrazones. J. Org. Chem. 2023, 88, 15881−��������15893 (SCI 二区TOP). 10. Xue-Song Zhang, Ya-Ping Han,* Yuecheng Zhang,* and Yong-Min Liang, Transition-Metal-Catalyzed Transformations Involving the Heck Reaction. Adv. Synth. Catal. 2023, 365, 2436–2466 (SCI 二区). 11. Bo-Ya Hao, Ya-Ping Han,* Yuecheng Zhang,* and Yong-Min Liang, New synthetic approaches toward OCF3-containing compounds. Org. Biomol. Chem. 2023, 21, 4926–4954 (SCI 三区). 12. Shao-Bo Duan, Hong-Yu Zhang, Yue Ma, Jiquan Zhao, Ya-Ping Han,* Yuecheng Zhang,* and Yong-Min Liang, Palladium-Catalyzed Intramolecular Heck Dearomative Alkenylation of Indoles with N‑��������Tosylhydrazones. J. Org. Chem. 2022, 87, 10917−��������10927 (SCI 二区TOP). 13. Zhao-Nan Cai, Xiang-Xuan Feng, Yuecheng Zhang, Cong-Cong Lu, Ya-Ping Han,* Jiquan Zhao*, Transition-Metal-Free Catalyzed Dehydrative Coupling of Quinoline and Isoquinoline N-Oxides with Propargylic Alcohols. Chin. J. Chem. 2022, 40, 71−��������78 (SCI 一区). 14. Cong-Cong Lu, Bo-Ya Hao, Ya-Ping Han,* and Yong-Min Liang*, Recent Advances in the Synthesis of Indolines via Dearomative Annulation of N-acylindoles. Asian J. Org. Chem. 2022, 11, 10, e202200312 (SCI 四区). 15. Yuanfeng Li; Hong-Yu Zhang; Yuecheng Zhang; Ya-Ping Han*; Jiquan Zhao*; Yong-Min Liang; Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Annulation of Aryl Halides to Furnish Indolines, J. Org. Chem, 2021, 86, 14640-14651 (SCI 二区TOP). 16. Duan, Shao-Bo; Zhang, Hong-Yu; Hao, Bo-Ya; Zhao, Jiquan; Han, Ya-Ping*; Zhang, Yuecheng; Liang*, Yong-Min; Palladium-catalyzed intramolecular diastereoselective dearomatization reaction of indoles with N-tosylhydrazones, Org. Chem. Front. 2021, 8, 5895-5901 (SCI 一区TOP). 17. Shao-Bo Duan, Xu-Jing Gao, Hong-Yu Zhang, Cong-Cong Lu, Jiquan Zhao, Ya-Ping Han*, Yuecheng Zhang*, Yong-Min Liang*. Palladium-catalyzed intramolecular tandem dearomatization of indoles for the synthesis of tetracyclic indolines, Arab. J. Chem. 2021, 14, 103155 (SCI 二区). 18. Yuanfeng Li, Yue-Su, Hong-Yu Zhang, Yuecheng Zhang, Dong-Han, Ya-Ping Han,* Jiquan Zhao,* and Yong-Min Liang; Synthesis of Tetracyclic Indolines through Palladium‐Catalyzed Asymmetric Dearomative reaction of Aryl Iodides, ChemistrySelect. 2021, 6, 4719 –4724 (SCI 四区). 奖励及荣誉： |
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科研项目 |
[1] 河北省自然科学基金，面上项目，B2024202006，三氟甲氧基自由基参与炔烃化合物串联反应研究，2024-01至2026-12，在研，主持。 [2] 河北省教育厅科学基金委员会，重点项目，ZD2021026，三氟甲氧基自由基参与炔烃串联反应构建烯基三氟甲氧基类化合物，2021-01至2023-12，结题，主持。 [3] 河北省自然科学基金委员会，青年基金项目，B2020202010，基于炔丙基类衍生物的串联反应研究，2020-01至2022-12，结题，主持 [4] 国家自然科学基金委员会，面上项目，21772075，基于丙炔醇的若干新颖串联反应研究，2018-01至2021-12，结题，参与 |
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论著专利 |
[1] 路易斯酸催化炔丙醇合成[5,6,5]含氧三环化合物及其制备方法，韩亚平,刘庆辉,李响,张雪松,刘嘉璇，已申请，申请号：2024104658146，申请日期：2024.04.18。 [2] 钯催化吲哚分子内脱芳构化合成吲哚啉喹啉衍生物及其制备方法，韩亚平,马岳,刘庆辉，已申请，申请号：2023114912581，申请日期：2023.11.10。 [3] 路易斯酸催化炔丙醇合成喹啉衍生物及其制备方法，韩亚平,李响,任喜燕,封向璇，已申请，申请号：2023110270167，申请日期：2023.08.16。 |
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招生方向 |
化学工程/化学工程与设计/生物技术与工程 |
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