研究领域

1.过渡金属催化

2.有机合成方法学

3.烯烃不对称环氧化反应

讲授课程

《药物合成反应》、《高等有机化学》、《天然药物化学》、《药物分析实验》

学术经历

2014-09-2019-06  兰州大学硕博连读

2019-07-至今     河北工业大学任教

学术兼职

无

学术成就

学术成就:

一直从事过渡金属催化的新型串联反应设计研究及应用，集中于有机合成化学中的新方法、新策略研究，具体工作涵盖路易斯酸或布朗斯特酸催化炔丙醇串联反应、钯催化卤代吲哚Heck脱芳构化反应、烯烃不对称环氧化反应等多个领域，以药物小分子骨架的高效合成为主。（1）路易斯酸或布朗斯特酸催化炔丙醇串联反应，以炔丙醇为底物，在路易斯酸或布朗斯特酸催化下与亲核试剂、亲核亲电试剂、双亲核试剂反应，实现系列普通炔烃难以进行的反应。（2）钯催化卤代吲哚Heck脱芳构化反应，以卤代吲哚化合物和N-对甲基苯磺酰腙为底物，在钯催化下发生分子内Heck反应，经过氧化加成、迁移插入、金属转移、还原消除等过程合成含有季碳中心的脱芳构二氢吲哚衍生物。迄今为止，在重要学术期刊上发表SCI论文50余篇，其中以通讯作者或第一作者在本学科领域共发表SCI论23篇，其中SCI二区及以上论文20篇，近五年论文情况如下：
  研究成果：

1. Jia-Xuan Liu, Sheng-Qi Xu, Ya-Ping Han,* Yong-Min Liang; Recent Advances in Cyclization Reactions of   1,6-Enynes. Adv. Synth.   Catal. 2024, 10.1002/adsc.202301480 (SCI 二区).

2. Qing-Hui Liu, Yue Ma, Hong-Yu Zhang, Yuecheng   Zhang, * Jiquan Zhao, Xiaohui Cao,* Ya-Ping Han,* and Yong-Min Liang; Experimental and   Computational Studies on the Palladium-catalyzed Intramolecular   Dearomatization, Electrophilic Addition, Intermolecular Coupling Sequence. Org. Chem. Front. 2024, 10.1039/D3QO02087H (SCI 一区TOP).

3. Xue-Song Zhang, Ya-Ping Han,* Yong-Min Liang; Recent   Advances in the Cascade Cyclization Reactions of 1,7-Enynes. Adv. Synth. Catal. 2024, 366, 324−356 (SCI 二区).

4. Xi-Yan Ren, Xiang-Xuan Feng, Hong-Yu Zhang, Yuecheng   Zhang,* Jiquan Zhao, Ya-Ping Han,* Yong-Min Liang; Lewis Acid Catalyzed [4 + 2]   Annulation of Propargylic Alcohols with 2-Vinylanilines. J. Org. Chem. 2023, 88, 16007−16017 (SCI 二区TOP).

5. Yue Ma, Qing-Hui Liu, Ya-Ping Han,* Palladium-Catalyzed   Enantioselective Intramolecular Heck Dearomative Annulation of Indoles with N‑Tosylhydrazones.   J. Org. Chem. 2023, 88, 15881−15893 (SCI 二区TOP).

6. Xue-Song Zhang, Ya-Ping Han,* Yuecheng   Zhang,* and Yong-Min Liang, Transition-Metal-Catalyzed Transformations   Involving the Heck Reaction. Adv. Synth. Catal. 2023, 365,   2436–2466 (SCI 二区).

7. Bo-Ya Hao, Ya-Ping Han,* Yuecheng   Zhang,* and Yong-Min Liang, New synthetic approaches toward OCF₃-containing   compounds. Org. Biomol. Chem. 2023, 21, 4926–4954 (SCI 三区).

8. Shao-Bo Duan, Hong-Yu Zhang, Yue Ma, Jiquan   Zhao, Ya-Ping Han,* Yuecheng Zhang,* and Yong-Min Liang, Palladium-Catalyzed   Intramolecular Heck Dearomative Alkenylation of Indoles with N‑Tosylhydrazones. J. Org. Chem. 2022, 87, 10917−10927 (SCI   二区TOP).

9. Zhao-Nan Cai, Xiang-Xuan Feng, Yuecheng Zhang, Cong-Cong Lu, Ya-Ping   Han,* Jiquan Zhao*, Transition-Metal-Free Catalyzed Dehydrative Coupling   of Quinoline and Isoquinoline N-Oxides   with Propargylic Alcohols. Chin. J. Chem. 2022, 40, 71−78 (SCI 一区).

10. Cong-Cong Lu, Bo-Ya Hao, Ya-Ping Han,* and Yong-Min   Liang*, Recent Advances in the Synthesis of Indolines via Dearomative Annulation   of N-acylindoles. Asian J. Org.   Chem. 2022, 11, 10, e202200312 (SCI 四区).

11. Yuanfeng Li; Hong-Yu Zhang; Yuecheng Zhang; Ya-Ping Han*; Jiquan   Zhao*; Yong-Min Liang; Palladium-Catalyzed Asymmetric Intramolecular   Dearomative Heck Annulation of Aryl Halides to Furnish Indolines, J. Org. Chem, 2021, 86, 14640-14651 (SCI 二区TOP).

12. Duan, Shao-Bo; Zhang, Hong-Yu; Hao, Bo-Ya; Zhao, Jiquan; Han,   Ya-Ping*; Zhang, Yuecheng; Liang*, Yong-Min; Palladium-catalyzed   intramolecular diastereoselective dearomatization reaction of indoles with N-tosylhydrazones,   Org. Chem. Front. 2021, 8, 5895-5901 (SCI 一区TOP).

13. Shao-Bo Duan, Xu-Jing Gao, Hong-Yu Zhang, Cong-Cong Lu, Jiquan Zhao, Ya-Ping   Han*, Yuecheng Zhang*, Yong-Min Liang*. Palladium-catalyzed   intramolecular tandem dearomatization of indoles for the synthesis of   tetracyclic indolines, Arab. J. Chem. 2021, 14, 103155 (SCI 二区).

14. Yuanfeng Li, Yue-Su, Hong-Yu Zhang, Yuecheng Zhang, Dong-Han, Ya-Ping   Han,* Jiquan Zhao,* and Yong-Min Liang; Synthesis of Tetracyclic   Indolines through Palladium‐Catalyzed Asymmetric Dearomative reaction of Aryl   Iodides, ChemistrySelect. 2021,   6, 4719 –4724 (SCI 四区).

15. Li-Juan, Du; Yuecheng, Zhang; Hong-Yu, Zhang; Guohui, Yin; Xiao-Yan,   Wang; Jiquan, Zhao*; Ya-Ping, Han*; Synthesis of   1,6-Dihydropyridine-3-carbonitrile Derivatives via Lewis Acid-Catalyzed   Annulation of Propargylic Alcohols with (E)-3-Amino-3-phenylacrylonitriles, J. Org. Chem. 2020, 85, 9863-9875 (SCI 二区TOP).

16. Li-Juan Du; Ya-Ping Han*; Hong-Yu Zhang; Yuecheng Zhang*;   Jiquan Zhao; Yong-Min Liang; Synthesis of 1H-Pyrrolo[1,2-a]indoles via Lewis   Acid-Catalyzed Annulation of Propargylic Alcohols with 2-Ethynylanilines, Adv. Synth. Catal. 2020, 362, 1399-1404 (SCI 二区).

奖励及荣誉：
  2016年与2018年分别荣获博士国家奖学金。

科研项目

河北省教育厅科学基金委员会，重点项目，ZD2021026，三氟甲氧基自由基参与炔烃串联反应构建烯基三氟甲氧基类化合物，2021-01至2023-12，10万元，在研，主持

河北省自然科学基金委员会，青年基金项目，B2020202010，基于炔丙基类衍生物的串联反应研究，2020-01至2022-12，6万元，结题，主持

国家自然科学基金委员会，面上项目，21772075，基于丙炔醇的若干新颖串联反应研究，2018-01至2021-12，64万元，结题，参与

论著专利

[1] 钯催化吲哚分子内脱芳构化合成吲哚啉喹啉衍生物及其制备方法，韩亚平,马岳,刘庆辉，已申请，申请号：2023114912581，申请日期：2023.11.10。

[2] 路易斯酸催化炔丙醇合成喹啉衍生物及其制备方法，韩亚平,李响,任喜燕,封向璇，已申请，申请号：2023110270167，申请日期：2023.08.16。

招生方向

化工/化学工程与设计/制药工程（选填）