研究领域

1.         生物医用高分子材料

2.         刺激响应高分子材料

3.         智能穿戴电子材料

讲授课程

《纳米材料》《先进功能材料》《高分子材料进展》

《生物高分子材料构建及其性能》

学术经历

2018年毕业于南开大学并获博士学位，同年11月到河北工业大学化工学院，高分子材料与工程系工作。

学术兼职

学术成就

从事纳米药物递送载体、水凝胶、静电纺丝支架、可穿戴电子材料等生物医用高分子材料的研究。在Advanced Science，Bioactive Materials，Biomaterials，Chemical Engineering   Journal，ACS Applied Materials & Interfaces等期刊发表多篇SCI论文。2018年入选河北工业大学“元光学者”启航岗B。

科研项目

1.  河北省自然科学基金青年基金，过氧化氢响应的一氧化氮阿霉素共递送系统构建及肿瘤化疗增敏研究，主持。

2.  河北省教育厅青年基金，基于自组装多肽的一氧化氮-阿霉素水凝胶用于肿瘤化疗增敏研究，主持。

3.       开放课题，GSH/GST响应的一氧化氮-阿霉素共递送系统的构建及其在耐药乳腺癌治疗中的应用，主持。

论著专利

1.         Peng Zhao, Yu Zhang, Xiaoai Chen, Chang Xu, Jingzhe Guo,   Meigui Deng, Xiongwei Qu, Pingsheng Huang*,   Zujian Feng*, Jimin Zhang*. Versatile Hydrogel Dressing with Skin Adaptiveness and   Mild Photothermal Antibacterial Activity for Methicillin-Resistant   Staphylococcus Aureus-Infected Dynamic Wound Healing, Advanced   Science, 2023, 2206585. IF 17.521.

2.         Xiaoai Chen, Chang Xu, Peng Zhao, Yu Zhang, Jingzhe   Guo, Xiuli Hu, Hui Gao, Chuangnian Zhang*,   Xiongwei Qu*, Jimin Zhang*. A multichannel Ca²⁺   nanomodulator amplifies exogenous and endogenous calcium overload for   efficient antitumor and antimetastasis therapy, Chemical Engineering   Journal, 2023, 142478. IF 16.744.

3.         Jimin Zhang,   Meigui Deng, Xiaoguang Shi, Chuangnian Zhang, Xiongwei Qu, Xiuli Hu*, Weiwei Wang*,   Deling Kong, Pingsheng Huang*. Cascaded   amplification of intracellular oxidative stress and reversion of multidrug   resistance by nitric oxide prodrug based-supramolecular hydrogel for   synergistic cancer chemotherapy[J]. Bioactive Materials, 2021,   6(10): 3300-3313. IF 16.874.

4.         Yu Zhang, Peng Zhao, Xiaoai Chen, Chang Xu, Jingzhe Guo,   Xiongwei Qu, Xiuli Hu, Hui Gao, Pingsheng Huang*, Jimin Zhang*, et al. Near Infrared-Activatable   Methylene Blue Polypeptide Codelivery of the NO Prodrug via π−π Stacking for Cascade Reactive Oxygen 3 Species   Amplification-Mediated Photodynamic Therapy, ACS Applied Materials   & Interfaces, 2023, 15: 12750-12765. IF 10.383.

5.         Jimin Zhang, Huijuan   Song, Shenglu Ji, Xiaomin Wang, Pingsheng Huang, Chuangnian Zhang, Weiwei   Wang*, Deling Kong*. NO prodrug-conjugated,   self-assembled, pH-responsive and galactose receptor targeted nanoparticles   for co-delivery of nitric oxide and doxorubicin. Nanoscale, 2018,   10, 4179-4188. IF 8.307.

6.         Chunyong Liang,   Jiying Song, Yongguang Zhang, Yaping Guo, Meigui Deng, Wei Gao*, Jimin Zhang*. Facile Approach to   Prepare rGO@Fe3O4 Microspheres for the Magnetically Targeted and   NIR-responsive Chemo-photothermal Combination Therapy. Nanoscale   Research Letters, 2020, 15(86): 1-11. IF 5.418.

7.         Peiqiong Zhao, Meigui   Deng, Yongfang Yang, Jimin Zhang*, Yue Zhang. Synthesis and Self-Assembly   of Thermoresponsive Biohybrid Graft Copolymers Based on a Combination of   Passerini Multicomponent Reaction and Molecular Recognition[J]. Macromolecular Rapid   Communications, 2021, 42(21): 2100424. IF 5.006.

8.         Jimin Zhang, Jianing Wang,   Yongzhen Wei, Cheng Gao, Xuejiao Chen, Wei Kong, Deling Kong*, Qiang   Zhao*. ECM-mimetic heparin glycosamioglycan-functionalized surface favors   constructing functional vascular smooth muscle tissue in vitro. Colloids   and Surfaces B: Biointerfaces, 2016, 146: 280-288.   IF 6.0.

9.         Qiang Zhao, Jimin   Zhang^#, Lijie Song, Qing Ji, Yao Yao, Yun Cui, Jie Shen*,   Peng George Wang*, Deling Kong*. Polysaccharide-based   biomaterials with on-demand nitric oxide releasing property regulated by   enzyme catalysis[J]. Biomaterials, 2013, 34(33), 8450-8458. IF 15.304.

10.     Chuangnian Zhang, Jimin   Zhang^#, Yibo Qin, Huijuan Song, Pingsheng Huang, Weiwei Wang,   Chun Wang, Chen Li, Yanming Wang*, Deling Kong*. Co-delivery of   doxorubicin and pheophorbide A by F127 micelles for chemo-photodynamic combination   therapy of melanoma. Journal of Materials Chemistry B, 2018, 6,   3305-3314. IF 7.571.

11.     Xiaomin Wang, Jimin   Zhang^#, Weilong Cui, Yuan Fang, Li Li, Shenglu Ji, Duo Mao, Tingyu Ke, Xin   Yao , Dan Ding, Guowei Feng*, Deling Kong*. Composite   hydrogel modified by IGF-1C domain improves stem cell therapy for limb   ischemia. ACS Applied Materials & Interfaces, 2018, 10(5), 4481–4493. IF 10.383.

12.     Xin Zhou, Jimin   Zhang^#, Guowei Feng, Jie Shen, Deling Kong*, Qiang Zhao*.   Nitric oxide-releasing biomaterials for biomedical applications[J]. Current   medicinal chemistry, 2016, 23(24): 2579-2601.   IF 4.74.

13.     廖日鑫, 李国华, 张计敏*, 胡秀丽, 瞿雄伟.聚氨基酸在肿瘤免疫治疗中的应用, 高分子材料科学与工程, 2021, 37(8): 182-190. EI

专利：

1. 张计敏，赵鹏，邓梅桂，陈小爱，张宇，瞿雄伟. 一种多功能抗菌水凝胶敷料的制备方法及应用，CN113999406A.  

2. 张计敏，邓梅桂，赵鹏，张宇，陈小爱. 一种用于级联递送药物的透明质酸纳米给药系统的制备方法，CN115501204A.  

3. 张计敏，邓梅桂，赵鹏，张宇，陈小爱，徐畅，郭靖喆，瞿雄伟. 一种光敏剂和一氧化氮前药的给药系统其及制备方法，CN115804849A.

招生方向

化学（学硕）、材料与化工（专硕）